Drug dosing in neonates

Once-daily-dosing intramuscular gentamicin in neonates.

Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children.

Neonates, infants, and children differ from adults in many aspects, not just in age, weight, and body composition. Growth, maturation and environmental factors affect drug kinetics, response and dosing in pediatric patients. Almost 80% of drugs have not been studied in children, and dosing of these drugs is derived from adult doses by adjusting for body weight/size. As developmental and maturat...

Assessment of kidney function for drug dosing.

The effort to improve the identification and management of patients with chronic kidney disease (CKD) is based on implementing more precise means of assessing kidney function and kidney damage in the clinical setting. Over the past decade, the clinical chemistry community has adopted routine reporting of estimated GFR (eGFR) calculated from the Modification of Diet in Renal Disease (MDRD) Study...

Drug dosing during continuous renal replacement therapy.

Continuous renal replacement therapy (CRRT) has given clinicians an important option in the care of critically ill patients. The slow and continuous dialysate and ultrafiltrate flow rates that are employed with CRRT can yield drug clearances similar to an analogous glomerular filtration rate of the native kidneys. Advantages such as superior volume control, excellent metabolic control, and hemo...

Light-triggered molecule-scale drug dosing devices.

The ability to control drug dosing in terms of quantity, location, and time is a key goal for drug delivery science,1 as improved control maximizes therapeutic effect while minimizing side effects.2 Systems responsive to a stimulus such as temperature,3 pH,4 applied magnetic5 or electrical6 field, ultrasound,7 light,8 or enzymatic action9 have been proposed as triggered delivery systems. Howeve...